Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595113 | 0.86 | POLB (0.35) | MAPTKMT2AKDM4EGAAALDH1A1 | |
| SCHEMBL4596765 | 0.81 | ALDH1A1 (0.48) | MAPTMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL4230267 | 0.77 | PRKAB2 (0.45) | MAPTMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL4596028 | 0.70 | PARP1 (0.33) | — | |
| SCHEMBL4596860 | 0.70 | PARP1 (0.36) | MAPTMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL11091102 | 0.70 | SMN1; SMN2 (0.35) | KMT2AALDH1A1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL4596690 | 0.69 | BRD4 (0.49) | — | |
| SCHEMBL4595116 | 0.68 | PARP1 (0.44) | KDM4EALDH1A1POLBMAPK14 | |
| SCHEMBL4649843 | 0.68 | HTR1A (0.40) | SMN1; SMN2HPGDTP53RAB9ANPC1 | |
| SCHEMBL6047939 | 0.68 | HTR2A (0.40) | ALDH1A1SMN1; SMN2RAB9ANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |