Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 5/20 | 0.33 |
| ▸ | AQP1 | P29972 | 3/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595596 | 0.86 | AQP1 (0.33) | CNR1CNR2HTR1AAQP1PLA2G7 | |
| SCHEMBL4595198 | 0.85 | LMNA (0.39) | BRD4CREBBPHTR1ASLC5A2PARP1 | |
| SCHEMBL4230237 | 0.83 | AQP1 (0.52) | CNR1CNR2HTR1AAQP1PLA2G7 | |
| SCHEMBL4710394 | 0.82 | CNR1 (0.38) | CNR1CNR2BRD4CREBBPHTR1A | |
| SCHEMBL4765146 | 0.81 | AQP1 (0.50) | CNR1CNR2BRD4CREBBPHTR1A | |
| SCHEMBL5583714 | 0.80 | CNR1 (0.39) | CNR1CNR2BRD4CREBBPHTR1A | |
| SCHEMBL4596349 | 0.79 | GRM2 (0.38) | CNR1CNR2BRD4CREBBPHTR1A | |
| SCHEMBL4595488 | 0.79 | MAPK14 (0.42) | CNR1CNR2 | |
| SCHEMBL4649844 | 0.79 | PARP1 (0.48) | CNR1CNR2BRD4CREBBPHTR1A | |
| SCHEMBL4596891 | 0.78 | THRB (0.39) | CNR1CNR2BRD4CREBBPHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2007030150-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH (US) | 2007-03-15 | — | — | WO | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |