Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | MIF | P14174 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380601 | 0.85 | SLC6A4 (0.47) | HIF1ALMNAKDM4EADRA1AHTR2A | |
| SCHEMBL27181475 | 0.81 | HIF1A (0.57) | HIF1ALMNAKDM4EADRB1ADRA1A | |
| SCHEMBL4596146 | 0.81 | L3MBTL1 (0.48) | LMNAADRA1AHTR1AADRA2ADRD1 | |
| SCHEMBL4596177 | 0.77 | SMN1; SMN2 (0.45) | LMNAKDM4ESLC6A3GAA | |
| SCHEMBL4596308 | 0.76 | ACHE (0.38) | ALDH1A1 | |
| SCHEMBL6176448 | 0.76 | LMNA (0.50) | HIF1ALMNAKDM4EADRB1ADRA1A | |
| SCHEMBL6176429 | 0.76 | LMNA (0.50) | HIF1ALMNAKDM4EADRB1ADRA1A | |
| SCHEMBL2808694 | 0.76 | LMNA (0.50) | HIF1ALMNAKDM4EADRB1ADRA1A | |
| SCHEMBL4595851 | 0.75 | ROCK1 (0.39) | LMNAKDM4EADRB1ADRB2ADRB3 | |
| SCHEMBL5205938 | 0.75 | OPRK1 (0.44) | HIF1ALMNAKDM4EADRB1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |