Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596091 | 0.88 | EPHX2 (0.33) | — | |
| SCHEMBL4595419 | 0.83 | CA12 (0.40) | ALDH1A1 | |
| SCHEMBL5548233 | 0.81 | CPN1 (0.37) | — | |
| SCHEMBL6119950 | 0.75 | EPHX2 (0.41) | ALDH1A1 | |
| SCHEMBL1567591 | 0.71 | CNR1 (0.33) | — | |
| SCHEMBL973034 | 0.71 | REN (0.33) | — | |
| SCHEMBL2028293 | 0.71 | CNR1 (0.37) | — | |
| SCHEMBL970849 | 0.70 | — | — | |
| SCHEMBL5548245 | 0.69 | SIGMAR1 (0.50) | — | |
| SCHEMBL4972141 | 0.69 | MAPK1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |