Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 8/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28179870 | 0.87 | PARP1 (0.38) | KIF11TDP2ASIC3 | |
| SCHEMBL28243392 | 0.83 | FEN1 (0.44) | TDP2CYP11B1CYP11B2 | |
| SCHEMBL28243419 | 0.81 | CA12 (0.42) | KIF11CA9CA12NISCHHRH3 | |
| SCHEMBL29964358 | 0.77 | NOTUM (0.36) | KIF11TDP2 | |
| SCHEMBL28293217 | 0.77 | NOTUM (0.36) | KIF11TDP2 | |
| SCHEMBL17026632 | 0.75 | CA9 (0.45) | KIF11CA9CA12NISCH | |
| SCHEMBL5009232 | 0.73 | ALDH1A1 (0.34) | NISCH | |
| SCHEMBL1479810 | 0.72 | TDP2 (0.68) | KIF11TDP2CHRNB2CHRNA4ASIC3 | |
| SCHEMBL30752216 | 0.72 | HRH4 (0.41) | ASIC3HRH3 | |
| SCHEMBL29458622 | 0.71 | ADRA2A (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105693645-B | Condensed heterocyclic compouds as ion channel modulators | 吉利德科学公司 | 2018-10-09 | — | — | CN | disclosed |
| CN-105693645-A | FUSED HETEROCYCLIC COMPOUNDS AS SODIUM CHANNEL MODULATORS | 吉利德科学公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-103649056-B | Fused heterocyclic compounds as modulators of ion channels | GILEAD SCIENCES, INC. (US) | 2016-04-27 | — | — | CN | disclosed |