Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596642 | 0.82 | ALDH1A1 (0.43) | EZH2MAP3K14ATMALDH1A1GAA | |
| SCHEMBL4597088 | 0.82 | HTR2A (0.47) | HTR2AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL15758803 | 0.81 | ERN1 (0.33) | HTR2AHTR2CERN1ALDH1A1GAA | |
| SCHEMBL4597001 | 0.81 | HTR7 (0.39) | HTR2AHTR2CHTR3A | |
| SCHEMBL4596512 | 0.79 | CYP1A1 (0.40) | HTR2AHTR2CHTTALDH1A1GAA | |
| SCHEMBL4768061 | 0.78 | PRKAB2 (0.37) | HTR2AHTR2CHTTALDH1A1GAA | |
| SCHEMBL4220760 | 0.77 | PRKAB2 (0.48) | EZH2MAP3K14HTR2AHTR2CATM | |
| SCHEMBL4713088 | 0.73 | HTR2C (0.40) | HTR2AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL4606789 | 0.72 | AQP1 (0.47) | HTR2AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL4596119 | 0.71 | HTR2A (0.41) | HTR2AHTR2CHTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2007030150-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH (US) | 2007-03-15 | — | — | WO | disclosed |