Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 15/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24112335 | 0.84 | METTL3 (0.55) | METTL3KIT | |
| SCHEMBL305699 | 0.83 | METTL3 (0.55) | METTL3KITPRMT5 | |
| SCHEMBL1134888 | 0.81 | CSF1R (0.56) | KITNPC1LMNACYP1A2CYP3A4 | |
| SCHEMBL29360810 | 0.81 | CSF1R (0.56) | KITNPC1LMNACYP1A2CYP3A4 | |
| SCHEMBL2587386 | 0.80 | METTL3 (0.53) | METTL3KITPRMT5 | |
| SCHEMBL260364 | 0.80 | NOS1 (0.52) | METTL3KITNPC1LMNACYP1A2 | |
| SCHEMBL30285533 | 0.80 | NOS1 (0.52) | METTL3KITNPC1LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL1056437 | 0.78 | NOS1 (0.50) | METTL3KITNPC1LMNACYP1A2 | |
| SCHEMBL7379757 | 0.78 | NOS1 (0.50) | METTL3KITNPC1LMNACYP1A2 | |
| SCHEMBL1134858 | 0.78 | NPC1 (0.60) | METTL3PRMT5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613781-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032065-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GLAXO GROUP LIMITED (GB) | 2012-03-15 | — | — | WO | disclosed |
| EP-2406255-A1 | 4-OXADIAZOL-2 -YL- INDAZOLES AS INHIBITORS OF P13 KINASES | Glaxo Group Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010102958-A1 | 4-OXADIAZOL-2 -YL- INDAZOLES AS INHIBITORS OF P13 KINASES | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |