Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | METTL3 | Q86U44 | 10/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1134947 | 0.87 | METTL3 (0.56) | NPC1RAB9AALDH1A1SMN1; SMN2METTL3 | |
| SCHEMBL12821441 | 0.79 | ALDH1A1 (0.60) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL459667 | 0.78 | METTL3 (0.52) | NPC1RAB9AMETTL3PRMT5 | |
| SCHEMBL13073501 | 0.76 | RAB9A (0.63) | NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL305699 | 0.76 | METTL3 (0.55) | METTL3PRMT5 | |
| SCHEMBL24112335 | 0.75 | METTL3 (0.55) | METTL3 | |
| SCHEMBL950058 | 0.75 | RAB9A (1.00) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL17738840 | 0.74 | PKM (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1134904 | 0.74 | HSP90AA1 (0.59) | METTL3 | |
| SCHEMBL30285533 | 0.74 | NOS1 (0.52) | NPC1RAB9AALDH1A1SMN1; SMN2METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285783-A1 | INDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009134666-A1 | INDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-05 | — | — | WO | disclosed |