Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | PPOX | P50336 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596411 | 0.94 | CYP11B1 (0.51) | CYP11B1CYP11B2LTB4RPTPN2PTPN1 | |
| SCHEMBL4890673 | 0.92 | CYP11B1 (0.50) | CYP11B1CYP11B2CHEK1POLBALDH1A1 | |
| SCHEMBL4596717 | 0.84 | CYP11B1 (0.45) | CYP11B1CYP11B2CHEK1MEN1TTR | |
| SCHEMBL4595112 | 0.76 | HDAC2 (0.47) | LTB4RPTPN2PTPN1PTPN6MEN1 | |
| SCHEMBL3903976 | 0.72 | KIF11 (0.51) | CHEK1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL4898796 | 0.72 | TTR (0.43) | CYP11B1CYP11B2CHEK1MEN1TTR | |
| SCHEMBL29182839 | 0.71 | NPC1 (0.44) | CYP11B1CYP11B2MEN1KMT2APOLB | |
| SCHEMBL19175209 | 0.71 | MASP2 (0.51) | MEN1KMT2ATDP1ALDH1A1PPARD | |
| SCHEMBL30930995 | 0.71 | NPC1 (0.44) | CYP11B1CYP11B2MEN1KMT2APOLB | |
| SCHEMBL3484477 | 0.71 | ALDH1A1 (0.52) | MEN1KMT2ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |