Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.31 |
| ▸ | CASP3 | P42574 | 2/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650698 | 0.82 | SMN1; SMN2 (0.35) | CASP3KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL4688433 | 0.81 | AQP1 (0.43) | NOTUMMAPK14 | |
| SCHEMBL4596878 | 0.75 | NOTUM (0.37) | NOTUMCRHR1GRM2HRH4CASP3 | |
| SCHEMBL4597187 | 0.75 | MYC (0.39) | HRH4 | |
| SCHEMBL4595395 | 0.73 | PARP1 (0.43) | NOTUM | |
| SCHEMBL4595393 | 0.72 | AQP1 (0.36) | NOTUMCRHR1GRM2TAAR1NPC1 | |
| SCHEMBL4226107 | 0.70 | AQP1 (0.41) | NOTUMHRH4KDM4EALDH1A1CYP1A2 | |
| SCHEMBL4226208 | 0.70 | AQP1 (0.55) | NOTUMGRM2HRH4TAAR1ALDH1A1 | |
| SCHEMBL29719717 | 0.70 | NOTUM (0.53) | NOTUMGRM2CASP3 | |
| SCHEMBL1479837 | 0.69 | CYP1A2 (0.43) | NOTUMGRM2KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |