Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.77 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.71 |
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | CA12 | O43570 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.65 |
| ▸ | CA2 | P00918 | 1/20 | 0.65 |
| ▸ | CA9 | Q16790 | 1/20 | 0.65 |
| ▸ | ALDH3A1 | P30838 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.65 |
| ▸ | CES2 | O00748 | 1/20 | 0.64 |
| ▸ | BCHE | P06276 | 1/20 | 0.64 |
| ▸ | CES1 | P23141 | 1/20 | 0.64 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.61 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16329852 | 0.92 | ACHE (0.83) | ACHEHSP90AA1TP53MAPTCA12 | |
| SCHEMBL29869527 | 0.88 | ALDH3A1 (0.82) | ACHETP53MAPTCA12CA1 | |
| SCHEMBL11186018 | 0.88 | ALDH3A1 (0.82) | ACHETP53MAPTCA12CA1 | |
| SCHEMBL14047967 | 0.87 | ACHE (0.75) | ACHEHSP90AA1TP53MAPTALDH3A1 | |
| SCHEMBL28053364 | 0.87 | ACHE (1.00) | ACHEHSP90AA1TP53MAPTALDH3A1 | |
| SCHEMBL22410741 | 0.87 | ACHE (0.75) | ACHEHSP90AA1TP53MAPTCA12 | |
| SCHEMBL578250 | 0.87 | ACHE (0.74) | ACHEHSP90AA1TP53MAPTCA12 | |
| SCHEMBL13627889 | 0.82 | ACHE (0.54) | ACHEHSP90AA1TP53MAPTCA12 | |
| SCHEMBL4597560 | 0.82 | ACHE (0.86) | ACHECA12CA1CA2CA9 | |
| SCHEMBL4597660 | 0.82 | CHRM5 (0.73) | ACHECA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541808-A | Metronidazole-isatin type compound as well as preparation method and application thereof | UNIV JISHOU | 2016-05-04 | — | — | CN | disclosed |
| WO-2008046083-A2 | USE OF OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-04-17 | — | — | WO | disclosed |
| EP-1877378-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-01-16 | — | — | EP | disclosed |
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2007-05-10 | — | — | US | disclosed |
| WO-2006113864-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | OPRL1, OPRK1, TRPV1 | ACHE 270/4885HSP90AA1 1489/4885TP53 4519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.