Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | ALDH2 | P05091 | 3/20 | 0.71 |
| ▸ | ALDH3A1 | P30838 | 3/20 | 0.71 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | CES1 | P23141 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 1/20 | 0.64 |
| ▸ | CASP3 | P42574 | 2/20 | 0.63 |
| ▸ | CASP7 | P55210 | 2/20 | 0.63 |
| ▸ | CASP6 | P55212 | 2/20 | 0.63 |
| ▸ | CASP1 | P29466 | 1/20 | 0.63 |
| ▸ | CASP4 | P49662 | 1/20 | 0.63 |
| ▸ | CASP9 | P55211 | 1/20 | 0.63 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28220867 | 0.91 | ACHE (0.63) | ACHEALDH1A1ALDH2ALDH3A1HSP90AA1 | |
| SCHEMBL16329852 | 0.91 | ACHE (0.83) | ACHEALDH1A1ALDH2ALDH3A1HSP90AA1 | |
| SCHEMBL27866584 | 0.88 | ALDH1A1 (0.67) | ACHEALDH1A1ALDH2ALDH3A1HSP90AA1 | |
| SCHEMBL4597228 | 0.87 | ACHE (0.77) | ACHEALDH1A1ALDH2ALDH3A1HSP90AA1 | |
| SCHEMBL16048068 | 0.85 | ALDH1A1 (0.71) | ACHEALDH1A1ALDH2ALDH3A1MAPT | |
| SCHEMBL28719173 | 0.85 | ACHE (0.56) | ACHEALDH1A1ALDH2ALDH3A1HSP90AA1 | |
| SCHEMBL22410741 | 0.85 | ACHE (0.75) | ACHEALDH1A1ALDH3A1HSP90AA1MAPT | |
| SCHEMBL28053364 | 0.85 | ACHE (1.00) | ACHEALDH1A1ALDH2ALDH3A1HSP90AA1 | |
| SCHEMBL14047967 | 0.85 | ACHE (0.75) | ACHEALDH1A1ALDH2ALDH3A1HSP90AA1 | |
| SCHEMBL16521837 | 0.85 | ACHE (0.56) | ACHEALDH1A1ALDH2ALDH3A1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107840851-A | Indoles spiral shell pyrrole alloxazine compounds and its synthetic method | 扬州大学 | 2018-03-27 | — | — | CN | claimed |
| CN-118459390-B | 3-Hydroxy oxindole derivative containing Z-type 1, 4-dicarbonyl olefin, and preparation method and application thereof | SUN YAT-SEN UNIVERSITY (CN) | 2026-05-26 | — | — | CN | disclosed |
| CN-118459390-A | 3-Hydroxy oxindole derivative containing Z-type 1, 4-dicarbonyl olefin, and preparation method and application thereof | 中山大学 | 2024-08-09 | — | — | CN | disclosed |
| US-11858915-B2 | Polo like kinase 4 inhibitors | ORIC PHARMACEUTICALS, INC. (US) | 2024-01-02 | — | — | US | disclosed |
| US-20230365537-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS, INC. | 2023-11-16 | — | — | US | disclosed |
| CN-114160206-B | Catalyst for catalytic synthesis of optically active indole compound, application and synthesis method thereof, and optically active indole compound | 中国科学技术大学 | 2023-03-10 | — | — | CN | disclosed |
| CN-114160206-A | Catalyst for catalytic synthesis of optically active indole compound, application and synthesis method thereof, and optically active indole compound | 中国科学技术大学 | 2022-03-11 | — | — | CN | disclosed |
| CN-111423421-B | Oxidized indole-substituted gamma-butenolide derivative and preparation method and application thereof | 中山大学 | 2021-09-03 | — | — | CN | disclosed |
| CN-111423421-A | Oxidized indole-substituted gamma-butenolide derivative and preparation method and application thereof | 中山大学 | 2020-07-17 | — | — | CN | disclosed |
| US-RE47731-E1 | Kinase inhibitors and method of treating cancer with same | UNIV HEALTH NETWORK (CA) | 2019-11-19 | — | — | US | disclosed |
| EP-2032584-A2 | THIADIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | Wyeth (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20080194563-A1 | Shp-2 Inhibitors, Pharmaceutical Compositons Comprising Them and Their Use For Treating Phosphatase-Mediated Diseases | MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20080125469-A1 | Thiadiazole compounds and methods of use thereof | WYETH (US) | 2008-05-29 | — | — | US | disclosed |
| WO-2007146138-A2 | THIADIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | WYETH (US) | 2007-12-21 | — | — | WO | disclosed |
| US-7250442-B2 | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2007-07-31 | — | — | US | disclosed |
| US-7250442-B2 | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2007-07-31 | — | — | US | disclosed |
| US-7250442-B2 | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2007-07-31 | — | — | US | disclosed |
| US-20050054712-A1 | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY | 2005-03-10 | — | — | US | disclosed |
| EP-1487792-A1 | DIHYDROINDOL-2-ONE DERIVATIVES AS STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078394-A1 | DIHYDROINDOL-2-ONE DERIVATIVES AS STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194563-A1 | Shp-2 Inhibitors, Pharmaceutical Compositons Comprising Them and Their Use For Treating Phosphatase-Mediated Diseases | PTPN2, PTPRJ, PTPRS | ACHE 4845/4885ALDH1A1 3914/4885ALDH2 2820/4885 |
| US-11858915-B2 | Polo like kinase 4 inhibitors | PLK4, PLK2, PLK3 | ACHE 4244/4885ALDH1A1 2211/4885ALDH2 1859/4885 |
| US-20230365537-A1 | POLO LIKE KINASE 4 INHIBITORS | PLK4, PLK2, PLK3 | ACHE 4244/4885ALDH1A1 2211/4885ALDH2 1859/4885 |
| US-20080125469-A1 | Thiadiazole compounds and methods of use thereof | ADAMTS5, ADAMTS1, TIMP3 | ACHE 204/4885ALDH1A1 388/4885ALDH2 277/4885 |
| US-20050054712-A1 | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators | NR3C2, NR5A1, NR5A2 | ACHE 4757/4885ALDH1A1 723/4885ALDH2 856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.