Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 3/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596620 | 0.84 | NPSR1 (0.38) | CXCR3CHRM2CHRM3 | |
| SCHEMBL4597890 | 0.80 | CXCR3 (0.39) | CXCR3CHRM2CHRM3 | |
| SCHEMBL4596509 | 0.78 | CYP2C19 (0.34) | CNR2CXCR3 | |
| SCHEMBL4597761 | 0.76 | KCNJ1 (0.44) | CHRM2CHRM3 | |
| SCHEMBL4597403 | 0.76 | CCR5 (0.52) | CCR5EGLN1CNR2CXCR3CHRM2 | |
| SCHEMBL5576322 | 0.68 | CCR5 (0.87) | CCR5 | |
| SCHEMBL4597703 | 0.65 | CCR5 (0.74) | CCR5 | |
| SCHEMBL5572337 | 0.64 | CCR5 (0.92) | CCR5 | |
| SCHEMBL4597841 | 0.63 | CCR5 (0.80) | CCR5 | |
| SCHEMBL5576372 | 0.63 | CCR5 (0.80) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |