Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 4/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596616 | 0.83 | CHRM3 (0.41) | CCR5CHRM2CHRM3CXCR3 | |
| SCHEMBL4597887 | 0.79 | CHRM3 (0.42) | CHRM2CHRM3CXCR3 | |
| SCHEMBL4597404 | 0.76 | CCR5 (0.45) | CCR5CHRM2CHRM3EGLN1CNR2 | |
| SCHEMBL4597759 | 0.75 | KCNJ1 (0.51) | — | |
| SCHEMBL4597256 | 0.74 | DRD2 (0.34) | CXCR3 | |
| SCHEMBL5576322 | 0.74 | CCR5 (0.87) | CCR5CCR4KCNH2 | |
| SCHEMBL4626226 | 0.74 | CCR5 (0.42) | CCR5CHRM2CHRM3 | |
| SCHEMBL4597896 | 0.68 | CCR5 (1.00) | CCR5CCR4KCNH2 | |
| SCHEMBL5576372 | 0.68 | CCR5 (0.80) | CCR5CCR4KCNH2 | |
| SCHEMBL5575471 | 0.68 | CCR5 (1.00) | CCR5CCR4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |