SCHEMBL4597564

SCHEMBL4597564

CN(C)C(=O)C(CNC(=O)OC(C)(C)C)c1ccc(Oc2ccccc2CCC(=O)NO)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 2/20 0.36
ADRB2 P07550 5/20 0.36
ADRB1 P08588 3/20 0.36
SYK P43405 1/20 0.35
MALT1 Q9UDY8 1/20 0.34
HTR1A P08908 2/20 0.34
HDAC8 Q9BY41 3/20 0.33
HDAC3 O15379 2/20 0.33
HDAC4 P56524 2/20 0.33
HDAC1 Q13547 2/20 0.33
HDAC7 Q8WUI4 2/20 0.33
HDAC2 Q92769 2/20 0.33
HDAC10 Q969S8 2/20 0.33
HDAC11 Q96DB2 2/20 0.33
HDAC6 Q9UBN7 2/20 0.33
HDAC9 Q9UKV0 2/20 0.33
HDAC5 Q9UQL6 2/20 0.33
CTSS P25774 1/20 0.32
CTSK P43235 1/20 0.32
SLC6A2 P23975 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5294187 0.88 SYK (0.39) ADRB2ADRB1SYKCTSSCTSK
SCHEMBL4597275 0.86 MMP13 (0.37) MMP13SYKHDAC8HDAC3HDAC4
SCHEMBL4597563 0.80 HDAC8 (0.49) MMP13HDAC8HDAC3HDAC4HDAC1
SCHEMBL14021785 0.80 HDAC8 (0.49) MMP13HDAC8HDAC3HDAC4HDAC1
SCHEMBL4597428 0.80 HDAC2 (0.43) SYKHDAC8HDAC3HDAC4HDAC1
SCHEMBL1932821 0.77 SYK (0.47) SYKMALT1CTSSCTSK
SCHEMBL5307198 0.77 SYK (0.41) MMP13SYKHDAC1CTSSCTSK
SCHEMBL4597735 0.76 CA2 (0.36) MMP13SYK
SCHEMBL4598537 0.75 GHSR (0.38) MMP13ADRB2ADRB1SYKMALT1
SCHEMBL14021778 0.73 FFAR1 (0.42) HDAC8HDAC1SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1907352-A2 NOVEL DERIVATIVES OF AMINO ACIDS FOR TREATMENT OF OBESITY AND RELATED DISORDERS Bexel Pharmaceuticals Inc (US) 2008-04-09 EP disclosed
WO-2007005774-A2 NOVEL DERIVATIVES OF AMINO ACIDS FOR TREATMENT OF OBESITY AND RELATED DISORDERS BEXEL PHARMACEUTICALS, INC. (US) 2007-01-11 WO disclosed