Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 4/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | PAK4 | O96013 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326499 | 0.70 | EGFR (0.43) | PTGER4CHEK1LRRK2HTTKDM4E | |
| SCHEMBL3441172 | 0.67 | CHRNB2 (0.32) | PTGER4CHEK1 | |
| SCHEMBL14689824 | 0.65 | GABRP (0.54) | PTGER4CHEK1KMT2AKDM4EALDH1A1 | |
| SCHEMBL20846081 | 0.64 | MET (0.41) | LRRK2NTRK1MET | |
| SCHEMBL744450 | 0.63 | ATIC (0.39) | IDH1CHEK1HTTKDM4EALDH1A1 | |
| SCHEMBL14689938 | 0.62 | CHEK1 (0.57) | CHEK1HTT | |
| SCHEMBL7214036 | 0.62 | HTT (0.49) | PTGER4LRRK2HTTKDM4EALDH1A1 | |
| SCHEMBL20125054 | 0.62 | BRD4 (0.44) | IDH1CHEK1HTTKDM4EALDH1A1 | |
| SCHEMBL28227220 | 0.62 | HPGDS (0.37) | IDH1HTTKDM4EALDH1A1LMNA | |
| SCHEMBL1268087 | 0.61 | SLC6A4 (0.41) | PTGER4MEN1KMT2ALRRK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064265-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |