Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CUL4A | Q13619 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | FHIT | P49789 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4613022 | 0.81 | ALDH1A1 (0.45) | ALDH1A1CYP1A2HPGDALOX5HSD17B10 | |
| SCHEMBL27646279 | 0.78 | CA2 (0.37) | ALDH1A1CYP1A2HPGDHSD17B10NPC1 | |
| SCHEMBL13609511 | 0.75 | ALDH1A1 (0.53) | ALDH1A1CYP1A2HPGDHSD17B10MAPT | |
| SCHEMBL595150 | 0.74 | ALDH1A1 (0.69) | ALDH1A1CYP1A2HPGDHSD17B10MAPT | |
| SCHEMBL9206657 | 0.73 | CUL4A (0.42) | ALDH1A1CYP1A2HPGDALOX5MAPT | |
| SCHEMBL999179 | 0.72 | SMN1; SMN2 (0.50) | ALDH1A1CYP1A2HPGDHSD17B10MAPT | |
| SCHEMBL7376204 | 0.70 | NUDT1 (0.49) | ALDH1A1ALOX5HSD17B10MAPTNPC1 | |
| SCHEMBL2321953 | 0.70 | ALDH1A1 (0.54) | ALDH1A1CYP1A2HPGDHSD17B10MAPT | |
| SCHEMBL9202295 | 0.69 | ALOX5 (0.44) | ALDH1A1CYP1A2HPGDALOX5HSD17B10 | |
| SCHEMBL10438826 | 0.69 | ALDH1A1 (0.40) | ALDH1A1CYP1A2HPGDALOX5HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910330-B1 | HETEROCYCLYLAMIDE-SUBSTITUTED THIAZOLES, PYRROLES AND THIOPHENES | AICURIS GMBH & CO KG (DE) | 2014-07-23 | — | — | EP | disclosed |
| EP-1910330-A1 | HETEROCYCLYLAMIDE-SUBSTITUTED THIAZOLES, PYRROLES AND THIOPHENES | Bayer HealthCare AG (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009578-A1 | HETEROCYCLYLAMIDE-SUBSTITUTED THIAZOLES, PYRROLES AND THIOPHENES | BAYER HEALTHCARE AG (DE) | 2007-01-25 | — | — | WO | disclosed |