Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 10/20 | 0.67 |
| ▸ | LOX | P28300 | 9/20 | 0.67 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7635169 | 0.92 | LOXL2 (0.67) | LOXL2LOXLMNAMEN1KMT2A | |
| SCHEMBL4599769 | 0.89 | MITF (0.58) | LOXL2LOXMEN1KMT2A | |
| SCHEMBL18049198 | 0.81 | LOXL2 (1.00) | LOXL2LOX | |
| SCHEMBL238350 | 0.80 | LOXL2 (0.59) | LOXL2LOX | |
| Hydrochloric Acid SCHEMBL18049234 | 0.80 | LOXL2 (1.00) | LOXL2LOX | |
| SCHEMBL3373348 | 0.80 | KCNK3 (0.74) | LOXL2LOXLMNAMEN1KMT2A | |
| SCHEMBL31580448 | 0.78 | PGR (0.62) | LOXL2LOXNR1H4LMNAMEN1 | |
| SCHEMBL4599900 | 0.77 | KMT2A (0.70) | MEN1KMT2ANPC1TP53RECQL | |
| SCHEMBL2868158 | 0.76 | KDM4C (0.64) | LMNAMEN1KMT2AKCNK3HTT | |
| SCHEMBL18049199 | 0.76 | LOXL2 (1.00) | LOXL2LOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910295-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | Bayer HealthCare AG (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007028456-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | BAYER HEALTHCARE AG (DE) | 2007-03-15 | — | — | WO | disclosed |
| WO-2007028456-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | BAYER HEALTHCARE AG (DE) | 2007-03-15 | — | — | WO | disclosed |