Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600130 | 0.85 | EGFR (0.47) | EGFRLMNATHRBTHRAKDM4E | |
| SCHEMBL6653138 | 0.83 | TP53 (0.47) | LMNAMAPTTHRBTHRAKDM4E | |
| SCHEMBL4602183 | 0.82 | EGFR (0.47) | EGFRGAAMAPTTHRBKMT2A | |
| SCHEMBL4601033 | 0.81 | EGFR (0.44) | EGFRTHRBTHRAKDM4EHTR2A | |
| SCHEMBL4600843 | 0.81 | RAB9A (0.50) | EGFRLMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL4601338 | 0.81 | EGFR (0.42) | EGFRTHRBTHRAKDM4ERXFP1 | |
| SCHEMBL8953416 | 0.81 | LMNA (0.41) | LMNAJAK2GAAMAPTKDM4E | |
| SCHEMBL4600628 | 0.79 | EGFR (0.47) | EGFRLMNAJAK2GAAMAPT | |
| SCHEMBL4602061 | 0.78 | PDE4B (0.42) | EGFRALDH1A1HTR2AGRM2KMT2A | |
| SCHEMBL4600070 | 0.78 | EGFR (0.42) | EGFRHTR2AGRM2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |