Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.60 |
| ▸ | CCR2 | P41597 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3616598 | 0.86 | PTGDR2 (0.59) | PTGDR2HPGDKDM4EALDH1A1TSHR | |
| SCHEMBL15361940 | 0.78 | PTGDR2 (0.58) | PTGDR2HPGDKDM4EALDH1A1USP2 | |
| SCHEMBL4613716 | 0.77 | CCR2 (0.54) | PTGDR2CCR2HPGDKDM4EALDH1A1 | |
| SCHEMBL15361967 | 0.76 | CCR2 (0.53) | PTGDR2CCR2HPGDKDM4EALDH1A1 | |
| SCHEMBL15362043 | 0.76 | CCR2 (0.55) | CCR2HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL4599679 | 0.76 | ALDH1A1 (0.54) | CCR2HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL2005637 | 0.75 | PTGDR2 (1.00) | PTGDR2KDM4EAKR1B1TSHR | |
| SCHEMBL4600229 | 0.74 | CCR2 (0.56) | CCR2HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL832189 | 0.73 | CCR2 (0.71) | CCR2HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL4777221 | 0.73 | PTGDR2 (0.70) | PTGDR2HPGDKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910335-B1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | SANOFI SA (FR) | 2013-11-06 | — | — | EP | claimed |
| EP-1910335-A1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2008-04-16 | — | — | EP | claimed |
| WO-2007010144-A1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2007-01-25 | — | — | WO | claimed |