Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CCR2 | P41597 | 4/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3622285 | 0.86 | NOD2 (0.51) | ALDH1A1KDM4EHSD17B10GAANPC1 | |
| SCHEMBL15362048 | 0.79 | RAB9A (0.43) | HDAC6GAANPC1RAB9ATSHR | |
| SCHEMBL4613716 | 0.77 | CCR2 (0.54) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL15361967 | 0.76 | CCR2 (0.53) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL4600655 | 0.76 | PTGDR2 (0.60) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL4600229 | 0.74 | CCR2 (0.56) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL12466547 | 0.74 | ALDH1A1 (0.66) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL4599865 | 0.74 | CCR2 (0.55) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL7378692 | 0.74 | ALDH1A1 (0.65) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL4599814 | 0.74 | CCR2 (0.55) | ALDH1A1KDM4EHPGDHSD17B10CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910335-B1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | SANOFI SA (FR) | 2013-11-06 | — | — | EP | claimed |
| EP-1910335-A1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2008-04-16 | — | — | EP | claimed |
| WO-2007010144-A1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2007-01-25 | — | — | WO | claimed |