Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | CA5A | P35218 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263003 | 0.77 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2CA1CA2 | |
| SCHEMBL3208037 | 0.77 | TAAR1 (0.50) | NPC1RAB9ASMN1; SMN2CA1CA2 | |
| SCHEMBL3217657 | 0.74 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2CA1CA2 | |
| SCHEMBL4031932 | 0.73 | POLB (0.69) | NPC1RAB9ASMN1; SMN2CA1CA2 | |
| SCHEMBL1046498 | 0.72 | POLB (0.50) | POLBALDH1A1LMNA | |
| SCHEMBL29145671 | 0.71 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2CA1CA2 | |
| Acetic Acid SCHEMBL27263112 | 0.70 | LMNA (0.53) | SMN1; SMN2POLBALDH1A1TSHRLMNA | |
| SCHEMBL7658914 | 0.70 | POLB (0.57) | NPC1RAB9ASMN1; SMN2POLBTAAR1 | |
| SCHEMBL12601569 | 0.70 | SMN1; SMN2 (0.45) | NPC1RAB9ASMN1; SMN2CA1CA2 | |
| SCHEMBL6564813 | 0.70 | TDP1 (0.56) | SMN1; SMN2CA1CA2POLBTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |