Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263003 | 0.79 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2TAAR1LMNA | |
| SCHEMBL2731878 | 0.77 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2TAAR1LMNA | |
| SCHEMBL3208037 | 0.76 | TAAR1 (0.50) | NPC1RAB9ASMN1; SMN2TAAR1LMNA | |
| Acetic Acid SCHEMBL27263112 | 0.75 | LMNA (0.53) | SMN1; SMN2LMNAMEN1KMT2APOLB | |
| SCHEMBL6564813 | 0.75 | TDP1 (0.56) | SMN1; SMN2TAAR1LMNAMEN1KMT2A | |
| SCHEMBL10689007 | 0.74 | CYP19A1 (0.48) | NPC1RAB9ASMN1; SMN2LMNAMEN1 | |
| SCHEMBL4600838 | 0.74 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2TAAR1LMNA | |
| SCHEMBL12601569 | 0.72 | SMN1; SMN2 (0.45) | NPC1RAB9ASMN1; SMN2TAAR1LMNA | |
| SCHEMBL2840589 | 0.72 | CA1 (0.48) | NPC1RAB9ASMN1; SMN2TAAR1LMNA | |
| SCHEMBL5574088 | 0.72 | ALDH1A1 (0.60) | NPC1RAB9ASMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041892-A1 | Therapeutic agent for diabetes | ABE HIDENORI | 2010-02-18 | — | — | US | disclosed |
| US-20090270631-A1 | Therapeutic agent for diabetes | ABE HIDENORI | 2009-10-29 | — | — | US | disclosed |
| US-20080009530-A1 | Therapeutic Agent for Diabetes | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270631-A1 | Therapeutic agent for diabetes | FABP4, SLC5A1, SLC5A2 | NPC1 1683/4885RAB9A 3599/4885SMN1; SMN2 3845/4885 |
| US-20080009530-A1 | Therapeutic Agent for Diabetes | FABP4, SLC5A1, SLC5A2 | NPC1 1377/4885RAB9A 3729/4885SMN1; SMN2 4093/4885 |
| US-20100041892-A1 | Therapeutic agent for diabetes | FABP4, SLC5A1, SLC5A2 | NPC1 1683/4885RAB9A 3599/4885SMN1; SMN2 3845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.