SCHEMBL4602209

SCHEMBL4602209

CCCCOC(=O)NC(CCN(C)C)C(=O)OC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
ALDH1A1 P00352 2/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
KDM4E B2RXH2 1/20 0.40
MAPT P10636 1/20 0.40
HPGD P15428 1/20 0.40
MCL1 Q07820 1/20 0.40
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
EPHX1 P07099 1/20 0.39
TAS1R3 Q7RTX0 1/20 0.39
TAS1R1 Q7RTX1 1/20 0.39
DNM1 Q05193 1/20 0.39
ACHE P22303 6/20 0.38
ZDHHC7 Q9NXF8 1/20 0.37
SIRT2 Q8IXJ6 1/20 0.37
SIRT1 Q96EB6 1/20 0.37
SIRT3 Q9NTG7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4631031 0.88 ITGB3 (0.42) MAPK1SMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL4631995 0.87 SMN1; SMN2 (0.39) MAPK1SMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL4603597 0.86 CTSL (0.38) MAPK1SMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL5199197 0.83 ACHE (0.44) ALDH1A1CA1CA2EPHX1TAS1R3
SCHEMBL5199193 0.83 ACHE (0.44) ALDH1A1CA1CA2EPHX1TAS1R3
SCHEMBL4632761 0.83 CHRNB2 (0.50) MAPK1SMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL5198185 0.82 ZDHHC7 (0.42) SMN1; SMN2ALDH1A1NPC1RAB9AHPGD
SCHEMBL12296373 0.82 HDAC2 (0.48) ALDH1A1CA1CA2EPHX1TAS1R3
SCHEMBL4778608 0.82 CA1 (0.41) ALDH1A1CA1CA2EPHX1TAS1R3
SCHEMBL1696818 0.81 CA1 (0.46) MAPK1SMN1; SMN2ALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004078116-A9 P38 INHIBITORS AND METHODS OF USE THEREOF ARRAY BIOPHARMA INC (US) 2008-09-12 WO disclosed
EP-1924568-A1 QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT SCHERING CORPORATION (US) 2008-05-28 EP disclosed
EP-1915351-A1 QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT SCHERING CORPORATION (US) 2008-04-30 EP disclosed
EP-1606283-A4 P38 INHIBITORS AND METHODS OF USE THEREOF ARRAY BIOPHARMA INC (US) 2007-05-23 EP disclosed
WO-2007011623-A1 QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT SCHERING CORPORATION (US) 2007-01-25 WO disclosed
WO-2007011618-A1 QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT SCHERING CORPORATION (US) 2007-01-25 WO disclosed
EP-1606283-A2 P38 INHIBITORS AND METHODS OF USE THEREOF Array Biopharma, Inc. (US) 2005-12-21 EP disclosed
WO-2004078116-A2 P38 INHIBITORS AND METHODS OF USE THEREOF ARRAY BIOPHARMA, INC. (US) 2004-09-16 WO disclosed