Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 7/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602209 | 0.87 | MAPK1 (0.40) | SMN1; SMN2RAB9ANPC1MAPK1MAPT | |
| SCHEMBL4631031 | 0.87 | ITGB3 (0.42) | SMN1; SMN2RAB9ANPC1MAPK1MAPT | |
| SCHEMBL7812490 | 0.86 | SIRT2 (0.44) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL4603597 | 0.82 | CTSL (0.38) | SMN1; SMN2RAB9ANPC1MAPK1MAPT | |
| SCHEMBL8141861 | 0.82 | EPHX1 (0.44) | SMN1; SMN2RAB9ANPC1MAPK1MAPT | |
| SCHEMBL4685971 | 0.81 | SIRT2 (0.43) | SMN1; SMN2RAB9ANPC1SIRT2EPHX1 | |
| SCHEMBL7278916 | 0.79 | RAB9A (0.42) | SMN1; SMN2RAB9ANPC1MAPTHPGD | |
| SCHEMBL7278909 | 0.79 | RAB9A (0.42) | SMN1; SMN2RAB9ANPC1MAPTHPGD | |
| SCHEMBL31023965 | 0.79 | NOD1 (0.42) | SMN1; SMN2RAB9ANPC1MAPK1MAPT | |
| SCHEMBL9565518 | 0.78 | ACHE (0.44) | SMN1; SMN2RAB9ANPC1EPHX1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924568-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007011623-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2007-01-25 | — | — | WO | disclosed |