Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | TACR2 | P21452 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21210714 | 0.98 | CYP3A4 (0.40) | CYP3A4CYP2D6TDP1L3MBTL1KCNH2 | |
| SCHEMBL23963172 | 0.98 | CYP3A4 (0.40) | CYP3A4CYP2D6TDP1L3MBTL1KCNH2 | |
| SCHEMBL19134142 | 0.98 | CYP3A4 (0.40) | CYP3A4CYP2D6TDP1L3MBTL1KCNH2 | |
| Hydrochloric Acid SCHEMBL3733909 | 0.98 | CYP3A4 (0.40) | CYP3A4CYP2D6TDP1L3MBTL1KCNH2 | |
| SCHEMBL5373758 | 0.94 | — | — | |
| SCHEMBL5537391 | 0.78 | ALDH1A1 (0.33) | CYP3A4TDP1ALDH1A1 | |
| SCHEMBL5544928 | 0.77 | — | — | |
| SCHEMBL21742813 | 0.76 | MEN1 (0.37) | L3MBTL1HRH3MAPTHRH4ALDH1A1 | |
| SCHEMBL20937684 | 0.74 | LMNA (0.37) | CYP3A4CYP2D6LMNA | |
| SCHEMBL23940063 | 0.73 | CYP3A4 (0.35) | CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109535143-B | Pyrazole amide derivative containing 5-aryl oxazole structure and preparation method and application thereof | 南通大学 | 2021-12-10 | — | — | CN | claimed |
| JP-5139030-A | — | — | None | — | — | JP | disclosed |
| US-11905258-B2 | 2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases | SOUTHERN RESEARCH INSTITUTE (US) | 2024-02-20 | — | — | US | disclosed |
| US-20230002331-A1 | 2-AMINOARYL-5-ARYLOXAZOLE ANALOGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SOUTHERN RES INST (US) | 2023-01-05 | — | — | US | disclosed |
| US-20210188791-A1 | 2-AMINOARYL-5-ARYLOXAZOLE ANALOGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SOUTHERN RESEARCH INSTITUTE | 2021-06-24 | — | — | US | disclosed |
| WO-2019164996-A1 | 2-AMINOARYL-5-ARYLOXAZOLE ANALOGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SOUTHERN RESEARCH INSTITUTE (US) | 2019-08-29 | — | — | WO | disclosed |
| US-20120022054-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | LABORATOIRE BIODIM (FR) | 2012-01-26 | — | — | US | disclosed |
| EP-2376431-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | LABORATOIRE BIODIM (FR) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010066847-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | CELLVIR (FR) | 2010-06-17 | — | — | WO | disclosed |
| CN-101679368-A | Aryl azoles, aryl diazole and benzimidizole derivatives | HOFFMANN LA ROCHE | 2010-03-24 | — | — | CN | disclosed |
| EP-0921800-A1 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-06-16 | — | — | EP | disclosed |
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5827869-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | disclosed |
| WO-1997029748-A1 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-21 | — | — | WO | disclosed |
| US-5612359-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| EP-0702012-A1 | Substituted isoxazole sulfonamides and their use as endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-03-20 | — | — | EP | disclosed |
| JP-H05139030-A | THERMAL RECORDING MATERIAL | MITSUI TOATSU CHEM INC | 1993-06-08 | — | — | JP | disclosed |
| US-4409231-A | HYPOTENSIVE AGENT | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1983-10-11 | — | — | US | disclosed |
| US-4409231-A | HYPOTENSIVE AGENT | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1983-10-11 | — | — | US | disclosed |
| US-4129661-A | 4,5-Dihydro-2-lower alkoxycarbonylamino-4-phenylimidazoles and substituted phenyl derivatives thereof | SYNTEX (U.S.A.) INC. (US) | 1978-12-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11905258-B2 | 2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases | SMN1; SMN2, TDP2, NFKBIA | CYP3A4 3458/4885CYP2D6 2564/4885TDP1 5/4885 |
| US-20120022054-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | HAVCR2, MAVS, EIF2AK2 | CYP3A4 22/4885CYP2D6 183/4885TDP1 4076/4885 |
| US-20230002331-A1 | 2-AMINOARYL-5-ARYLOXAZOLE ANALOGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SMN1; SMN2, TDP2, NFKBIA | CYP3A4 3458/4885CYP2D6 2564/4885TDP1 5/4885 |
| US-20210188791-A1 | 2-AMINOARYL-5-ARYLOXAZOLE ANALOGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SMN1; SMN2, TDP2, NFKBIA | CYP3A4 3458/4885CYP2D6 2564/4885TDP1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.