Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22163870 | 0.82 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNAHTTMEN1 | |
| SCHEMBL4602771 | 0.81 | ALDH1A1 (0.49) | ALDH1A1KDM4ELMNAHTTMEN1 | |
| SCHEMBL4601925 | 0.81 | KDM4E (0.54) | ALDH1A1KDM4ELMNAHTTKMT2A | |
| SCHEMBL30309550 | 0.80 | GPR183 (0.49) | ALDH1A1KDM4ELMNAHTTMEN1 | |
| SCHEMBL22172226 | 0.80 | GPR183 (0.49) | ALDH1A1KDM4ELMNAHTTMEN1 | |
| SCHEMBL4602168 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KDM4ELMNAHTTCYP1A2 | |
| SCHEMBL22172319 | 0.76 | ALDH1A1 (0.54) | ALDH1A1KDM4EHTTPOLB | |
| SCHEMBL13495620 | 0.75 | SMN1; SMN2 (0.67) | ALDH1A1KDM4EHTT | |
| SCHEMBL16620680 | 0.75 | KDM4E (0.62) | ALDH1A1KDM4EHTT | |
| SCHEMBL22172215 | 0.74 | NR1H2 (0.49) | ALDH1A1KDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |