SCHEMBL4602355

SCHEMBL4602355

CCCC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)N1CCC(NC(=O)c2ccc(OC)cc2)CC1)C(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.43
MEN1 O00255 2/20 0.43
ALDH1A1 P00352 2/20 0.43
DPP4 P27487 1/20 0.41
DPP8 Q6V1X1 1/20 0.41
DPP9 Q86TI2 1/20 0.41
MMP2 P08253 1/20 0.41
MMP3 P08254 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
BMP1 P13497 1/20 0.40
PDF Q9HBH1 1/20 0.40
TSHR P16473 1/20 0.40
TP53 P04637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4601223 0.91 PDF (0.42) KMT2AMEN1BMP1PDFTSHR
SCHEMBL4884598 0.91 PDF (0.42) KMT2AMEN1BMP1PDFTSHR
SCHEMBL4602747 0.91 PDF (0.41) ALDH1A1MMP2MMP3BMP1PDF
SCHEMBL4604487 0.91 KMT2A (0.41) KMT2AMEN1MMP2MMP3PDF
SCHEMBL4602320 0.90 NPSR1 (0.46) KMT2AMEN1MMP2MMP3BMP1
SCHEMBL13333263 0.90 LMNA (0.45) KMT2AMEN1ALDH1A1MMP2MMP3
SCHEMBL4884508 0.89 KMT2A (0.44) KMT2AMEN1ALDH1A1DPP4DPP8
SCHEMBL4601109 0.89 KMT2A (0.44) KMT2AMEN1ALDH1A1DPP4DPP8
SCHEMBL14075631 0.88 KMT2A (0.42) KMT2AMEN1ALDH1A1DPP4DPP8
SCHEMBL4885175 0.85 MMP3 (0.56) MMP2MMP3PDF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof KANG JAE-HOON 2008-09-25 US disclosed
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof KANG JAE-HOON 2008-09-25 US disclosed
EP-1915342-A1 A NOVEL HYDROXAMIC ACID DERIVATIVE AS PEPTIDE DEFORMYLASE INHIBITOR AND MANUFACTURING METHOD THEREOF Ildong Pharmaceutical Co., Ltd. (KR) 2008-04-30 EP disclosed
WO-2006115353-A9 A NOVEL HYDROXAMIC ACID DERIVATIVE AS PEPTIDE DEFORMYLASE INHIBITOR AND MANUFACTURING METHOD THEREOF ILDONG PHARMACEUTICAL CO LTD (KR) 2007-03-22 WO disclosed
WO-2006115353-A1 A NOVEL HYDROXAMIC ACID DERIVATIVE AS PEPTIDE DEFORMYLASE INHIBITOR AND MANUFACTURING METHOD THEREOF ILDONG PHARMACEUTICAL CO., LTD. (KR) 2006-11-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof PDF, PEPD, DHPS KMT2A 1445/4885MEN1 3235/4885ALDH1A1 2155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.