Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.48 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963548 | 0.76 | CA12 (0.47) | LMNARAB9AMAPTKMT2AMEN1 | |
| SCHEMBL4600923 | 0.76 | LMNA (0.55) | LMNATDP1CYP1A2RAB9AKDM4E | |
| SCHEMBL966590 | 0.74 | CA12 (0.49) | RAB9AMAPTKMT2AHTTHPGD | |
| SCHEMBL3220191 | 0.74 | LMNA (0.56) | LMNATDP1CYP1A2RAB9APKM | |
| SCHEMBL963555 | 0.73 | HSD11B1 (0.46) | LMNARAB9AMAPTKMT2AMEN1 | |
| SCHEMBL966298 | 0.73 | CA12 (0.50) | KMT2AHPGDMEN1L3MBTL1POLB | |
| SCHEMBL962182 | 0.73 | L3MBTL1 (0.48) | LMNARAB9APKMKMT2AMEN1 | |
| SCHEMBL964483 | 0.73 | MEN1 (0.44) | RAB9AMAPTKMT2AHTTHPGD | |
| SCHEMBL4616855 | 0.72 | RAB9A (0.67) | LMNATDP1RAB9APKMKDM4E | |
| SCHEMBL3196995 | 0.71 | LMNA (0.59) | LMNATDP1CYP1A2RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |