Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27849251 | 0.85 | NPC1 (0.53) | HTR1AGAASGMS2KMT2APTGER1 | |
| SCHEMBL4603320 | 0.83 | MAPT (0.43) | SGMS2KMT2APTGER1PTGER4PTGER3 | |
| SCHEMBL6026935 | 0.83 | NPC1 (0.51) | GAASGMS2PTGER1PTGER4PTGER3 | |
| SCHEMBL4602183 | 0.82 | EGFR (0.47) | HTR1AADRA1DADRA1AADRA1BGAA | |
| SCHEMBL27866136 | 0.82 | RXRA (0.53) | SGMS2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL4602703 | 0.82 | SGMS2 (0.43) | GAASGMS2KMT2APTGER1PTGER4 | |
| SCHEMBL5345373 | 0.80 | HTR1A (0.51) | HTR1AADRA1DADRA1AADRA1BRAB9A | |
| SCHEMBL1952684 | 0.79 | HTR1A (0.63) | HTR1AADRA1DADRA1AADRA1BGAA | |
| SCHEMBL4601601 | 0.78 | EGFR (0.47) | GAAKMT2AMAPTPTPN1HTT | |
| SCHEMBL8070513 | 0.77 | THRB (0.41) | GAAKMT2AMAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |