Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 9/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2772679 | 1.00 | DNM1 (0.48) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| Water SCHEMBL17222518 | 0.95 | SLC22A1 (0.48) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| Bromide SCHEMBL557385 | 0.95 | ALDH1A1 (0.52) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL315435 | 0.91 | DNM1 (0.44) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL8500446 | 0.90 | SLC22A1 (0.41) | DNM1SLC22A1TSHRHSD17B10SLC22A2 | |
| Hydrochloric Acid SCHEMBL2764924 | 0.89 | DNM1 (0.43) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| SCHEMBL8500577 | 0.87 | SLC22A1 (0.43) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| SCHEMBL17222516 | 0.87 | SLC22A1 (0.41) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| Bromide SCHEMBL3028711 | 0.85 | SLC22A1 (0.41) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| Phosphoric Acid SCHEMBL10748115 | 0.84 | GGPS1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329681-B2 | Methods and compositions for the efficient delivery of therapeutic agents to cells and animals | UNIVERSITY OF MASSACHUSETTS (US) | 2012-12-11 | — | — | US | disclosed |
| EP-1940775-A2 | METHODS AND COMPOSITIONS FOR THE EFFICIENT DELIVERY OF THERAPEUTIC AGENTS TO CELLS AND ANIMALS | University of Massachusetts (US) | 2008-07-09 | — | — | EP | disclosed |
| US-20070260055-A1 | Methods and compositions for the efficient delivery of therapeutic agents to cells and animals | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-11-08 | — | — | US | disclosed |
| WO-2007022030-A2 | METHODS AND COMPOSITIONS FOR THE EFFICIENT DELIVERY OF THERAPEUTIC AGENTS TO CELLS AND ANIMALS | UNIVERSITY OF MASSACHUSETTS (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070260055-A1 | Methods and compositions for the efficient delivery of therapeutic agents to cells and animals | ABCB4, PIGS, CETP | DNM1 144/4885SLC22A1 767/4885ALDH1A1 1072/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.