Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14485349 | 0.82 | ALDH1A1 (0.62) | ALDH1A1KMT2AGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL21590283 | 0.79 | MAPT (0.48) | ALDH1A1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL14922277 | 0.79 | ALDH1A1 (0.67) | ALDH1A1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL12291137 | 0.77 | ALDH1A1 (0.50) | ALDH1A1GAALMNASMN1; SMN2DRD2 | |
| SCHEMBL30609639 | 0.77 | HTR3A (0.61) | HTR7 | |
| SCHEMBL4142914 | 0.77 | DRD2 (0.45) | ALDH1A1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL706971 | 0.77 | HTR3A (0.61) | HTR7 | |
| SCHEMBL7711112 | 0.77 | ALDH1A1 (0.46) | ALDH1A1KMT2AGAALMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL709707 | 0.76 | HTR3A (0.59) | LMNAHTR7MAPT | |
| SCHEMBL13419298 | 0.76 | ALDH1A1 (0.59) | ALDH1A1KMT2AGAALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188290-B2 | Reacting secondary amine, carbon dioxide, triarylsilyl chloride and halogenation agent | GLAXO GROUP LIMITED (GB) | 2012-05-29 | — | — | US | claimed |
| US-20080262234-A1 | Process for Preparing N, N-Substituted Carbamoyl Halides | GLAXO GROUP LIMITED | 2008-10-23 | — | — | US | claimed |
| EP-1940783-A1 | PROCESS FOR PREPARING N, N-SUBSTITUTED CARBAMOYL HALIDES | GLAXO GROUP LIMITED (GB) | 2008-07-09 | — | — | EP | claimed |
| WO-2007048642-A1 | PROCESS FOR PREPARING N, N-SUBSTITUTED CARBAMOYL HALIDES | GLAXO GROUP LIMITED (GB) | 2007-05-03 | — | — | WO | claimed |
| US-11603368-B2 | Fused thiophene derivatives and their uses | ENYO PHARMA (FR) | 2023-03-14 | — | — | US | disclosed |
| EP-3749658-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | ENYO Pharma (FR) | 2020-12-16 | — | — | EP | disclosed |
| US-20200369682-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | ENYO PHARMA (FR) | 2020-11-26 | — | — | US | disclosed |
| WO-2019154949-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | ENYO PHARMA (FR) | 2019-08-15 | — | — | WO | disclosed |
| US-8188290-B2 | Reacting secondary amine, carbon dioxide, triarylsilyl chloride and halogenation agent | GLAXO GROUP LIMITED (GB) | 2012-05-29 | — | — | US | disclosed |
| CN-101959513-A | Novel pharmaceutical composition | GLAXO GROUP LTD | 2011-01-26 | — | — | CN | disclosed |
| CN-101641099-A | Pharmaceutical composition comprising 3, 5-diamino-6- (2, 3-dichlorophenyl) -1, 2, 4-triazine or R (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethylpyrimidine and NK1 | GLAXO GROUP LTD GB | 2010-02-03 | — | — | CN | disclosed |
| CN-101641102-A | Pharmaceutical compositions comprising NK1 receptor antagonists and sodium channel blockers | GLAXO GROUP LTD GB | 2010-02-03 | — | — | CN | disclosed |
| CN-101568341-A | Composition comprising an nk-1 receptor antagonist and an ssri for the treatment of tinnitus and hearing loss | GLAXO GROUP LTD (GB) | 2009-10-28 | — | — | CN | disclosed |
| US-20080262234-A1 | Process for Preparing N, N-Substituted Carbamoyl Halides | GLAXO GROUP LIMITED | 2008-10-23 | — | — | US | disclosed |
| EP-1940783-A1 | PROCESS FOR PREPARING N, N-SUBSTITUTED CARBAMOYL HALIDES | GLAXO GROUP LIMITED (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007048642-A1 | PROCESS FOR PREPARING N, N-SUBSTITUTED CARBAMOYL HALIDES | GLAXO GROUP LIMITED (GB) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200369682-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | FTH1, SLC40A1, FECH | ALDH1A1 2143/4885KMT2A 3454/4885GAA 267/4885 |
| US-11603368-B2 | Fused thiophene derivatives and their uses | FTH1, SLC40A1, FECH | ALDH1A1 2143/4885KMT2A 3454/4885GAA 267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.