Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | CCR3 | P51677 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MGLL | Q99685 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951323 | 0.86 | NPC1 (0.52) | HRH1CCR3MGLLEPHX2ALDH1A1 | |
| SCHEMBL4603638 | 0.83 | PDE4B (0.52) | RAB9AHRH1CCR3GAAMGLL | |
| SCHEMBL5318563 | 0.81 | EPHX2 (0.52) | HRH1CCR3GAAHSD11B1EPHX2 | |
| SCHEMBL1808176 | 0.80 | HRH1 (0.53) | RAB9AHRH1CCR3MGLLEPHX2 | |
| SCHEMBL1809962 | 0.80 | MGLL (0.64) | HRH1CCR3MGLLEPHX2SRD5A1 | |
| SCHEMBL12188726 | 0.79 | MGLL (0.67) | MGLLALDH1A1KMT2A | |
| SCHEMBL23775392 | 0.78 | RAB9A (0.72) | RAB9AGAAMGLLTDP1CYP2C9 | |
| SCHEMBL24590609 | 0.77 | RAB9A (0.55) | RAB9AHRH1CCR3GAAMGLL | |
| SCHEMBL1809256 | 0.77 | MGLL (0.68) | HRH1CCR3GAAMGLLCYP2C9 | |
| SCHEMBL4603682 | 0.76 | LMNA (0.55) | KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |
| EP-1609789-A1 | UREIDO-PYRAZOLE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-12-28 | — | — | EP | disclosed |