Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563414 | 0.75 | LMNA (0.41) | LMNAFDPS | |
| SCHEMBL992 | 0.73 | DGAT1 (0.41) | LMNAFDPS | |
| SCHEMBL9515430 | 0.72 | DGAT1 (0.39) | — | |
| SCHEMBL10923610 | 0.72 | ELANE (0.34) | — | |
| SCHEMBL1239900 | 0.71 | DGAT1 (0.44) | LMNAFDPS | |
| SCHEMBL9697626 | 0.71 | DGAT1 (0.39) | LMNAFDPS | |
| SCHEMBL4758776 | 0.70 | — | — | |
| SCHEMBL8563422 | 0.70 | ALDH1A1 (0.41) | LMNAFDPS | |
| SCHEMBL10012387 | 0.70 | — | — | |
| SCHEMBL19582475 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1944307-A2 | Synthetic Salicylihalamides, Apicularens and Derivatives Thereof | Board of Regents, The University of Texas System (US) | 2008-07-16 | — | — | EP | disclosed |
| US-6936723-B2 | Synthetic salicylihalamides, apicularens and derivatives thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2005-08-30 | — | — | US | disclosed |
| US-20040171672-A1 | Synthetic salicylihalamides, apicularens and derivatives thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2004-09-02 | — | — | US | disclosed |
| US-6734209-B2 | MACROCYCLIC LACTONES HAVING ANTI-CANCER ACTIVITY AND VACUOLAR ATPASE INHIBITORY ACTIVITY | BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM | 2004-05-11 | — | — | US | disclosed |
| US-20040063778-A1 | Synthetic salicylihalamides, apicularens and derivatives thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2004-04-01 | — | — | US | disclosed |
| US-6617348-B1 | Treating or preventing osteoporosis | UT SOUTHWESTERN MEDICAL CENTER | 2003-09-09 | — | — | US | disclosed |
| EP-1307439-A2 | SYNTHETIC SALICYLIHALAMIDES, APICULARENS AND DERIVATIVES THEREOF | Board of Regents, The University of Texas System (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012223-A2 | SYNTHETIC SALICYLIHALAMIDES, APICULARENS AND DERIVATIVES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063778-A1 | Synthetic salicylihalamides, apicularens and derivatives thereof | ATP6V1H, ATP6V1G1, ATP6V1A | LMNA 3509/4885FDPS 64/4885 |
| US-20040171672-A1 | Synthetic salicylihalamides, apicularens and derivatives thereof | ATP6V1H, ATP6V1G1, ATP6V1A | LMNA 3509/4885FDPS 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.