Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 3/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | PGK2 | P07205 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563422 | 0.87 | ALDH1A1 (0.41) | LMNAFDPS | |
| SCHEMBL992 | 0.81 | DGAT1 (0.41) | LMNAFDPSPGK1PGK2CA2 | |
| SCHEMBL9697626 | 0.79 | DGAT1 (0.39) | LMNAFDPSCA2 | |
| SCHEMBL1239900 | 0.79 | DGAT1 (0.44) | LMNAFDPS | |
| SCHEMBL4603883 | 0.75 | LMNA (0.35) | LMNAFDPS | |
| SCHEMBL1450701 | 0.75 | CYP4F2 (0.41) | LMNAFDPSKDM4EMEN1KMT2A | |
| SCHEMBL2242184 | 0.72 | FDPS (0.39) | LMNAFDPS | |
| SCHEMBL2087244 | 0.71 | LMNA (0.45) | LMNAFDPSPGK1PGK2CA2 | |
| SCHEMBL1336319 | 0.71 | LMNA (0.45) | LMNAFDPSPGK1PGK2MEN1 | |
| SCHEMBL8563162 | 0.69 | LMNA (0.32) | LMNAFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526642-B1 | TRITERPENE DERIVATIVE | SHIONOGI & CO (JP) | 1998-04-01 | — | — | EP | claimed |
| EP-0526642-A1 | TRITERPENE DERIVATIVE | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1993-02-10 | — | — | EP | claimed |
| EP-0526642-B1 | TRITERPENE DERIVATIVE | SHIONOGI & CO (JP) | 1998-04-01 | — | — | EP | disclosed |
| US-5248807-A | Endothelin antagonists, treatment of cardiovascular disorders | SHIONOGI & CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| EP-0526642-A1 | TRITERPENE DERIVATIVE | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1993-02-10 | — | — | EP | disclosed |