Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL128033 | 1.00 | HCAR2 (0.55) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL8927919 | 1.00 | HCAR2 (0.55) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL8927918 | 1.00 | HCAR2 (0.55) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL29356091 | 1.00 | HCAR2 (0.55) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL8563806 | 0.88 | HCAR2 (0.44) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Monomethyl Fumarate SCHEMBL3262884 | 0.88 | HCAR2 (0.77) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Monomethyl Fumarate SCHEMBL9797085 | 0.88 | HCAR2 (0.77) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Acrylic Acid SCHEMBL6856274 | 0.85 | — | — | |
| Acetic Acid SCHEMBL9511037 | 0.81 | — | — | |
| Maleic Acid SCHEMBL28537821 | 0.81 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 625 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313068-B1 | ORAL COMPOSITIONS AND USES THEREOF | COLGATE PALMOLIVE CO (US) | 2021-03-17 | — | — | EP | claimed |
| CN-110339069-A | A kind of firm medicament | 新乡医学院三全学院 | 2019-10-18 | — | — | CN | claimed |
| CN-109467793-A | A kind of transparent multiple-factor degradation modification polyethylene film and preparation method thereof | 江南大学 | 2019-03-15 | — | — | CN | claimed |
| CN-105854075-B | One kind is based on methyl vinyl ether maleic acid copolymer/chondroitin sulfate pH sensitivity composite hydrogels and preparation method thereof | 东南大学 | 2018-10-02 | — | — | CN | claimed |
| US-20180265424-A1 | NOVEL FERTILIZER | UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT | 2018-09-20 | — | — | US | claimed |
| CN-105147527-B | A kind of the study of denture adhesive | 博爱新开源医疗科技集团股份有限公司 | 2018-06-05 | — | — | CN | claimed |
| CN-105854075-A | Methyl vinyl ether and maleic acid copolymer/chondroitin sulfate-based pH-sensitive composite hydrogel and preparation method thereof | 东南大学 | 2016-08-17 | — | — | CN | claimed |
| US-20160185679-A1 | NOVEL FERTILIZER | UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT | 2016-06-30 | — | — | US | claimed |
| CN-105670310-A | Composite light-sensitive double-network hydrogel based on methyl vinyl ether maleic acid copolymer/alginic acid and preparation method of composite light-sensitive double-network hydrogel | 东南大学 | 2016-06-15 | — | — | CN | claimed |
| CN-105646893-A | Injectable self-healing hydrogel based on methyl vinyl ether-maleic acid copolymer/sodium alginate oxide and preparation method thereof | 东南大学 | 2016-06-08 | — | — | CN | claimed |
| US-5079140-A | Diagnosis Of Urine Samples | MILES INC. (US) | 1992-01-07 | — | — | US | claimed |
| EP-0431218-A2 | Silicone hairspray compositions | THE PROCTER & GAMBLE COMPANY (US) | 1991-06-12 | — | — | EP | claimed |
| EP-0431219-A1 | Silicone hairspray compositions | THE PROCTER & GAMBLE COMPANY (US) | 1991-06-12 | — | — | EP | claimed |
| US-4983377-A | SILICONE GUM, UNSOLUBILIZED PARTICULATE MATTER, HYDROPHOBIC CLAY, VOLATILE CARRIER | THE PROCTER & GAMBLE COMPANY (US) | 1991-01-08 | — | — | US | claimed |
| US-4983418-A | SILICONE GUM, DISPERSING AID, VOLATILE CARRIER | THE PROCTER & GAMBLE COMPANY (US) | 1991-01-08 | — | — | US | claimed |
| EP-0370764-A2 | Hair care compositions | THE PROCTER & GAMBLE COMPANY (US) | 1990-05-30 | — | — | EP | claimed |
| US-4352878-A | INCLUSION OF DIHYDRIC ALCOHOL IN COATING COMPOSITION TO RETARD DRYING | HITACHI, LTD. (JP) | 1982-10-05 | — | — | US | claimed |
| US-4196271-A | 2-CYANOACRYLATE, POLYCARBOXYLIC ACID IMPACT STRENGTH IMPROVER | TOAGOSEI CHEMICAL INDUSTRY CO., LTD. (JP) | 1980-04-01 | — | — | US | claimed |
| US-4157417-A | FOR APPLICATION TO WINDOW GLASS | ITD Industries Inc. (US) | 1979-06-05 | — | — | US | claimed |
| US-4046584-A | LIQUID CONCRETE ACCELERATING MIXTURES AND METHODS FOR USE THEREOF | SNYDER RAYMOND C | 1977-09-06 | — | — | US | claimed |