Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2275504 | 0.84 | IGF2BP2 (0.56) | DHODHPKMHDAC2ACLYIGF2BP2 | |
| SCHEMBL4617520 | 0.81 | PRSS12 (0.56) | DHODHKDM4EALDH1A1ABL1HDAC1 | |
| SCHEMBL4604120 | 0.80 | ACLY (0.58) | KDM4EALDH1A1HDAC1HDAC2ACLY | |
| SCHEMBL3918325 | 0.80 | HDAC1 (0.64) | KDM4EALDH1A1ABL1HDAC1HDAC2 | |
| SCHEMBL4221963 | 0.79 | DHODH (0.49) | DHODHCAMKK2FFAR4ACLY | |
| SCHEMBL4602392 | 0.76 | HDAC1 (0.56) | DHODHKDM4EALDH1A1ABL1HDAC1 | |
| SCHEMBL1316613 | 0.76 | SCN10A (0.49) | DHODHALDH1A1ABL1CAMKK2ACLY | |
| SCHEMBL4604019 | 0.75 | SMN1; SMN2 (0.47) | GAAALDH1A1HDAC1HDAC2RXFP1 | |
| SCHEMBL2270149 | 0.74 | ACLY (0.57) | KDM4EALDH1A1HDAC1HDAC2ACLY | |
| SCHEMBL4222995 | 0.74 | KDM4E (0.52) | KDM4EACLYIGF2BP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940786-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007031791-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-03-22 | — | — | WO | disclosed |