SCHEMBL1316613

SCHEMBL1316613

O=C(Nc1cc(-c2ccccc2OC(F)(F)F)ccc1C(=O)O)c1cncc(-c2ccccc2)c1.[NaH]

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SCN10A Q9Y5Y9 2/20 0.49
IGF2BP2 Q9Y6M1 1/20 0.49
ABL1 P00519 7/20 0.47
ACLY P53396 2/20 0.47
OPRM1 P35372 1/20 0.47
KCNH2 Q12809 1/20 0.47
DHODH Q02127 1/20 0.45
ALDH1A1 P00352 1/20 0.43
CAMKK2 Q96RR4 1/20 0.42
CSNK2A2 P19784 1/20 0.42
CSNK2B P67870 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1316610 0.91 SCN10A (0.48) SCN10AIGF2BP2ABL1OPRM1KCNH2
SCHEMBL1317879 0.86 ACLY (0.50) ACLYDHODHALDH1A1
SCHEMBL2275504 0.86 IGF2BP2 (0.56) SCN10AIGF2BP2ACLYDHODH
SCHEMBL1317577 0.86 IGF2BP2 (0.58) SCN10AIGF2BP2ABL1ACLYOPRM1
SCHEMBL15127674 0.86 ACLY (0.47) SCN10AIGF2BP2ACLYDHODHALDH1A1
SCHEMBL1317262 0.85 ACLY (0.52) IGF2BP2ACLYDHODHALDH1A1
SCHEMBL1318129 0.85 MKNK1 (0.49) SCN10AABL1ACLYDHODHALDH1A1
SCHEMBL1316295 0.85 ALDH1A1 (0.47) ABL1ACLYDHODHALDH1A1CAMKK2
SCHEMBL1317189 0.84 ACLY (0.51) SCN10AACLYDHODHALDH1A1
SCHEMBL1319364 0.83 ACLY (0.52) SCN10AACLYDHODHALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 SCN10A 820/4885IGF2BP2 3771/4885ABL1 849/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.