SCHEMBL2275504

SCHEMBL2275504

O=C(Nc1cc(-c2ccccc2OC(F)(F)F)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
IGF2BP2 Q9Y6M1 1/20 0.56
DHODH Q02127 2/20 0.53
SCN10A Q9Y5Y9 1/20 0.51
ACLY P53396 2/20 0.50
MEN1 O00255 2/20 0.50
PKM P14618 2/20 0.50
KMT2A Q03164 2/20 0.50
MAPT P10636 1/20 0.50
GRIK1 P39086 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
KCNK2 O95069 1/20 0.46
KCNK10 P57789 1/20 0.46
KCNK3 O14649 1/20 0.46
KCNK9 Q9NPC2 1/20 0.46
HDAC2 Q92769 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1316613 0.86 SCN10A (0.49) IGF2BP2DHODHSCN10AACLY
SCHEMBL2273065 0.84 MAPK1 (0.57) DHODHACLYMEN1PKMKMT2A
SCHEMBL4604141 0.84 DHODH (0.48) IGF2BP2DHODHACLYPKMHDAC2
SCHEMBL2272429 0.83 IGF2BP2 (0.71) IGF2BP2DHODHACLYMEN1PKM
SCHEMBL5147436 0.83 PYGL (0.54)
SCHEMBL2276941 0.81 IGF2BP2 (0.68) IGF2BP2DHODHACLYMEN1PKM
SCHEMBL2269612 0.81 HDAC1 (0.53) DHODHACLYMEN1PKMKMT2A
SCHEMBL4221963 0.81 DHODH (0.49) DHODHACLY
SCHEMBL2270359 0.80 MEN1 (0.57) DHODHACLYMEN1PKMKMT2A
SCHEMBL2276609 0.79 PKM (0.59) DHODHACLYMEN1PKMKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 IGF2BP2 4173/4885DHODH 1469/4885SCN10A 1529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.