Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 10/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | HNF4A | P41235 | 1/20 | 0.50 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2270149 | 0.93 | ACLY (0.57) | ACLYHDAC3HDAC1HDAC2KDM4E | |
| SCHEMBL4617520 | 0.86 | PRSS12 (0.56) | ACLYHDAC3HDAC1HDAC2KDM4E | |
| SCHEMBL3918325 | 0.85 | HDAC1 (0.64) | ACLYHDAC3HDAC1HDAC2KDM4E | |
| SCHEMBL28170369 | 0.82 | ALDH1A1 (0.60) | HDAC3HDAC1HDAC2KDM4EALDH1A1 | |
| SCHEMBL16404476 | 0.82 | ALDH1A1 (0.60) | HDAC3HDAC1HDAC2KDM4EALDH1A1 | |
| SCHEMBL11727165 | 0.81 | ACLY (0.62) | ACLYHDAC3HDAC1HDAC2GRIK1 | |
| SCHEMBL4602392 | 0.81 | HDAC1 (0.56) | ACLYHDAC3HDAC1HDAC2KDM4E | |
| SCHEMBL4604141 | 0.80 | DHODH (0.48) | ACLYHDAC3HDAC1HDAC2KDM4E | |
| SCHEMBL2276115 | 0.80 | MEN1 (0.49) | ACLYKDM4EALDH1A1 | |
| SCHEMBL2270696 | 0.80 | GAA (0.60) | KDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940786-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007031791-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-03-22 | — | — | WO | disclosed |