Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | UCHL5 | Q9Y5K5 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16068165 | 0.86 | TEK (0.53) | TEKKDREPHB4PRMT5UCHL5 | |
| SCHEMBL14987759 | 0.83 | TEK (0.55) | TEKKDREPHB4PRMT5UCHL5 | |
| SCHEMBL16264699 | 0.80 | TEK (0.57) | TEKKDREPHB4PRMT5UCHL5 | |
| SCHEMBL30722374 | 0.80 | TEK (0.57) | TEKKDREPHB4PRMT5UCHL5 | |
| SCHEMBL28311174 | 0.80 | TEK (0.55) | TEKKDREPHB4PRMT5UCHL5 | |
| SCHEMBL16155356 | 0.79 | HDAC3 (0.53) | TEKKDRUCHL5HDAC8HDAC6 | |
| SCHEMBL19086277 | 0.79 | HSP90AB1 (0.52) | TEKKDRUCHL5HDAC8HDAC6 | |
| SCHEMBL16155169 | 0.78 | HDAC3 (0.54) | TEKKDRUCHL5HDAC8HDAC6 | |
| SCHEMBL5014475 | 0.77 | NAMPT (0.68) | TEKKDREPHB4HDAC8HDAC6 | |
| SCHEMBL16155361 | 0.77 | HDAC3 (0.56) | UCHL5HDAC8HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613630-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | Cempra Pharmaceuticals, Inc. (US) | 2013-07-17 | — | — | EP | claimed |
| US-20130172280-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | CEMPRA PHARMACEUTICALS, INC. (US) | 2013-07-04 | — | — | US | claimed |
| WO-2012034058-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | CEMPRA PHARMACEUTICALS, INC. (US) | 2012-03-15 | — | — | WO | claimed |
| US-9815863-B2 | Hydrogen bond forming fluoro ketolides for treating diseases | CEMPRA PHARMACEUTICALS, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| EP-2613630-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | Cempra Pharmaceuticals, Inc. (US) | 2013-07-17 | — | — | EP | disclosed |
| US-20130172280-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | CEMPRA PHARMACEUTICALS, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| WO-2012034058-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | CEMPRA PHARMACEUTICALS, INC. (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172280-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | Q6ZSR9, LSS, LCT | TEK 2483/4885KDR 4612/4885EPHB4 4852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.