Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.68 |
| ▸ | NPC1 | O15118 | 6/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | AHR | P35869 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11492748 | 0.88 | MAPT (0.62) | MAPTNPC1KMT2APTPN1ALDH1A1 | |
| SCHEMBL29502948 | 0.83 | KMT2A (0.51) | MAPTNPC1KMT2APTPN1ALDH1A1 | |
| SCHEMBL647309 | 0.83 | KMT2A (0.51) | MAPTNPC1KMT2APTPN1ALDH1A1 | |
| SCHEMBL429754 | 0.81 | MAPT (1.00) | MAPTNPC1KMT2APTPN1ALDH1A1 | |
| SCHEMBL28428346 | 0.81 | MAPT (0.66) | MAPTNPC1KMT2APTPN1ALDH1A1 | |
| SCHEMBL30608270 | 0.81 | NPC1 (0.66) | MAPTNPC1KMT2APTPN1ALDH1A1 | |
| SCHEMBL10613511 | 0.79 | CA12 (0.69) | MAPTKMT2AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL650804 | 0.78 | ALDH1A1 (0.54) | MAPTNPC1KMT2APTPN1ALDH1A1 | |
| SCHEMBL1490754 | 0.78 | KDM4E (0.49) | MAPTNPC1KMT2APTPN1ALDH1A1 | |
| SCHEMBL11393520 | 0.78 | CA12 (0.62) | MAPTNPC1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685122-B1 | BENZOFURANS AND BENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2008-07-09 | — | — | EP | claimed |
| US-7371774-B2 | Benzofurans and benzothiophenes | MERCK PATENT GMBH (DE) | 2008-05-13 | — | — | US | claimed |
| US-20070066680-A1 | Benzofurans and benzothiophenes | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | claimed |
| CN-1882562-A | Benzofurans and benzothiophenes | MERCK PATENT GMBH (DE) | 2006-12-20 | — | — | CN | claimed |
| US-20060228313-A1 | Method of cosmetic depigmentation care by applying at least one aurone | COLETICA (FR) | 2006-10-12 | — | — | US | claimed |
| EP-1709964-A2 | A method of cosmetic depigmentation care by applying at least one aurone | ENGELHARD LYON (FR) | 2006-10-11 | — | — | EP | claimed |
| EP-1685122-A1 | BENZOFURANS AND BENZOTHIOPHENES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | claimed |
| WO-2005054226-A1 | BENZOFURANS AND BENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2005-06-16 | — | — | WO | claimed |
| WO-2000000194-A1 | OPHTHALMIC USES OF PPARGAMMA AGONISTS AND PPARGAMMA ANTAGONISTS | PHOTOGENESIS, INC. (US) | 2000-01-06 | — | — | WO | claimed |
| CN-108440470-A | A kind of synthetic method of 2- butyl -3- (4- hydroxy benzoyls) benzofuran | 瑞孚信江苏药业股份有限公司 | 2018-08-24 | — | — | CN | disclosed |
| US-20140135359-A1 | METHODS OF DESIGNING, PREPARING, AND USING NOVEL PROTONOPHORES | MARTINEAU LOUIS C (CA) | 2014-05-15 | — | — | US | disclosed |
| CN-101830872-A | Synthetic method of 3-hydroxyl benzofuran derivatives | UNIV SOUTHERN MEDICAL | 2010-09-15 | — | — | CN | disclosed |
| EP-1685122-B1 | BENZOFURANS AND BENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| EP-1685122-B1 | BENZOFURANS AND BENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| EP-1685122-A1 | BENZOFURANS AND BENZOTHIOPHENES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005054226-A1 | BENZOFURANS AND BENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2005-06-16 | — | — | WO | disclosed |
| WO-2004037248-A2 | MODULATION OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ACTIVITY | CAREX SA (FR) | 2004-05-06 | — | — | WO | disclosed |
| CN-1479736-A | Benzofuran and benzothiophene derivatives | - | 2004-03-03 | — | — | CN | disclosed |
| EP-0448850-B1 | 2-Alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia | TARO PHARMA IND (IL) | 1995-08-30 | — | — | EP | disclosed |
| US-3983245-A | CORONARY VASODILATORS | SMITHKLINE CORPORATION (US) | 1976-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060228313-A1 | Method of cosmetic depigmentation care by applying at least one aurone | TYR, MITF, MC1R | MAPT 1368/4885NPC1 3885/4885KMT2A 1643/4885 |
| US-20140135359-A1 | METHODS OF DESIGNING, PREPARING, AND USING NOVEL PROTONOPHORES | UQCRC2, UQCRC1, TIMM50 | MAPT 4702/4885NPC1 2404/4885KMT2A 3551/4885 |
| US-20070066680-A1 | Benzofurans and benzothiophenes | INSR, GPR119, IGF1R | MAPT 1767/4885NPC1 2244/4885KMT2A 2846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.