Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1426641 | 0.98 | HSD17B10 (0.47) | HSD17B10ALDH1A1LMNAMAPTKDM4E | |
| Sulfuric Acid SCHEMBL3400219 | 0.89 | HSD17B10 (0.41) | HSD17B10ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL3118165 | 0.88 | MAPT (0.50) | HSD17B10ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL3118058 | 0.82 | ALDH1A1 (0.36) | HSD17B10ALDH1A1LMNAMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL5711289 | 0.80 | HSD17B10 (0.44) | HSD17B10ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL2516919 | 0.78 | HSD17B10 (0.45) | HSD17B10ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL1426816 | 0.72 | KMT2A (0.46) | ALDH1A1LMNAMAPTKDM4EMEN1 | |
| SCHEMBL839103 | 0.71 | ALOX15 (0.30) | — | |
| Bromide SCHEMBL1457139 | 0.71 | KMT2A (0.45) | ALDH1A1LMNAMAPTKDM4EMEN1 | |
| Sulfuric Acid SCHEMBL5711512 | 0.71 | HSD17B10 (0.39) | HSD17B10ALDH1A1LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1944010-B1 | Brightening and/or colouring agent with acrylic acid derivative(s) | HENKEL AG & CO KGAA (DE) | 2015-03-11 | — | — | EP | disclosed |
| EP-1972323-A2 | Hair colorant | Henkel AG & Co. KGaA (DE) | 2008-09-24 | — | — | EP | disclosed |
| EP-1944010-A2 | Brightening and/or colouring agent with acrylic acid derivative(s) | Henkel AG & Co. KGaA (DE) | 2008-07-16 | — | — | EP | disclosed |