Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.38 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.38 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4806154 | 0.81 | AKR1C3 (0.56) | AKR1C3AKR1C2HDAC2DHODHMAPT | |
| SCHEMBL820380 | 0.79 | AKR1C3 (0.66) | AKR1C3HSD17B10SLC9A1ALDH1A1SLC9A3 | |
| SCHEMBL7824296 | 0.79 | AKR1C3 (0.66) | AKR1C3HSD17B10SLC9A1ALDH1A1SLC9A3 | |
| SCHEMBL5225714 | 0.76 | AKR1C3 (0.55) | AKR1C3SLC9A1SLC9A3SLC9A2APEX1 | |
| SCHEMBL5225717 | 0.76 | AKR1C3 (0.55) | AKR1C3SLC9A1SLC9A3SLC9A2APEX1 | |
| SCHEMBL7209266 | 0.75 | AKR1C3 (0.59) | AKR1C3APEX1TBXAS1 | |
| SCHEMBL2081756 | 0.73 | AKR1C3 (0.42) | AKR1C3AKR1C2CNR1APEX1TBXAS1 | |
| SCHEMBL2081758 | 0.73 | AKR1C3 (0.42) | AKR1C3AKR1C2CNR1APEX1TBXAS1 | |
| SCHEMBL3095394 | 0.73 | AKR1C3 (0.71) | AKR1C3SLC9A1ALDH1A1SLC9A3SLC9A2 | |
| SCHEMBL7204993 | 0.73 | AKR1C3 (0.61) | AKR1C3APEX1KMT2ATBXAS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943213-A2 | PPAR MODULATING BIAROMATIC COMPOUNDS | Galderma Research & Development (FR) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007049158-A2 | PPAR MODULATING BIAROMATIC COMPOUNDS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2007-05-03 | — | — | WO | disclosed |