SCHEMBL4806154

SCHEMBL4806154

CC(=Cc1ccc(-c2cccc(C)c2)cc1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.56
TP53 P04637 1/20 0.49
PTGS2 P35354 2/20 0.46
HSD17B1 P14061 1/20 0.44
HSD17B2 P37059 1/20 0.44
POLB P06746 2/20 0.43
MAPT P10636 1/20 0.43
CTDSP1 Q9GZU7 1/20 0.43
TRIM24 O15164 1/20 0.43
TRIM33 Q9UPN9 1/20 0.43
DHODH Q02127 2/20 0.42
PPARG P37231 1/20 0.42
PPARA Q07869 1/20 0.42
AKR1C2 P52895 1/20 0.41
AKR1C1 Q04828 1/20 0.41
TBXAS1 P24557 3/20 0.41
HDAC2 Q92769 1/20 0.41
GRIA2 P42262 1/20 0.40
GRIA4 P48058 1/20 0.40
MEN1 O00255 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL532624 0.85 AKR1C3 (0.77) AKR1C3TP53POLBMAPTTBXAS1
SCHEMBL532625 0.85 AKR1C3 (0.77) AKR1C3TP53POLBMAPTTBXAS1
SCHEMBL4806412 0.83 AKR1C3 (0.62) AKR1C3TP53PTGS2POLBMAPT
SCHEMBL3414243 0.83 AKR1C3 (0.72) AKR1C3TP53PTGS2POLBTBXAS1
SCHEMBL2732933 0.83 AKR1C3 (0.72) AKR1C3TP53PTGS2POLBTBXAS1
SCHEMBL7824296 0.82 AKR1C3 (0.66) AKR1C3TP53PTGS2MAPTTBXAS1
SCHEMBL3095394 0.82 AKR1C3 (0.71) AKR1C3TP53PTGS2MAPTTRIM24
SCHEMBL820380 0.82 AKR1C3 (0.66) AKR1C3TP53PTGS2MAPTTBXAS1
SCHEMBL4605752 0.81 AKR1C3 (0.45) AKR1C3MAPTDHODHAKR1C2TBXAS1
SCHEMBL4225892 0.81 AKR1C3 (0.51) AKR1C3TP53PTGS2POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7416821-B2 Thermally cured undercoat for lithographic application FUJIFILM ELECTRONIC MATERIALS, U.S.A., INC. (US) 2008-08-26 US disclosed
EP-1743363-A2 THERMALLY CURED UNDERCOAT FOR LITHOGRAPHIC APPLICATION FujiFilm Electronic Materials USA, Inc. (US) 2007-01-17 EP disclosed
US-20050238997-A1 Thermally cured undercoat for lithographic application FUJIFILM ELECTRONIC MATERIALS, U.S.A., INC. 2005-10-27 US disclosed
WO-2005089150-A2 THERMALLY CURED UNDERCOAT FOR LITHOGRAPHIC APPLICATION FUJIFILM ELECTRONIC MATERIALS USA INC. (US) 2005-09-29 WO disclosed