Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | OGG1 | O15527 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SENP5 | Q96HI0 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4634437 | 0.89 | PTPN2 (0.56) | CXCR2PTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL4605385 | 0.86 | CXCR2 (0.48) | CXCR2PTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL4632974 | 0.85 | ALDH1A1 (0.61) | CXCR2ALDH1A1KMT2ALMNAMAPK1 | |
| SCHEMBL4605051 | 0.82 | GABRA1 (0.54) | CXCR2PTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL4605344 | 0.82 | MAOB (0.59) | CXCR2PTPN1ALDH1A1KMT2ALMNA | |
| SCHEMBL4606976 | 0.82 | MAOB (0.44) | CXCR2PTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL4602716 | 0.81 | CXCR2 (0.54) | CXCR2PTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL4604246 | 0.80 | CXCR2 (0.53) | CXCR2PTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL4605238 | 0.79 | CXCR2 (0.52) | CXCR2PTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL4633854 | 0.78 | ALDH1A1 (0.47) | CXCR2PTPN2PTPN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685122-B1 | BENZOFURANS AND BENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| US-7371774-B2 | Benzofurans and benzothiophenes | MERCK PATENT GMBH (DE) | 2008-05-13 | — | — | US | disclosed |
| US-20070066680-A1 | Benzofurans and benzothiophenes | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066680-A1 | Benzofurans and benzothiophenes | INSR, GPR119, IGF1R | CXCR2 1633/4885PTPN2 2576/4885PTPN1 2031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.