Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | CNR2 | P34972 | 5/20 | 0.53 |
| ▸ | CNR1 | P21554 | 2/20 | 0.51 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.46 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.46 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4605385 | 0.91 | CXCR2 (0.48) | MAOBCNR2SENP5SENP2SENP1 | |
| SCHEMBL4606976 | 0.89 | MAOB (0.44) | MAOBCNR2CNR1SENP5SENP2 | |
| SCHEMBL4605051 | 0.89 | GABRA1 (0.54) | MAOBCNR2SENP5SENP2SENP1 | |
| SCHEMBL4604741 | 0.85 | MAOB (0.60) | MAOBCNR2CNR1SENP5SENP2 | |
| SCHEMBL4603763 | 0.85 | MAOB (0.44) | MAOBCNR2CNR1ESR1KMT2A | |
| SCHEMBL4606183 | 0.82 | CXCR2 (0.48) | SENP5SENP2SENP1CXCR2KMT2A | |
| SCHEMBL4634437 | 0.82 | PTPN2 (0.56) | SENP5SENP2SENP1CXCR2KMT2A | |
| SCHEMBL4604069 | 0.80 | MAOB (0.54) | MAOBCNR2CNR1SENP5SENP2 | |
| SCHEMBL4605095 | 0.78 | SENP5 (0.38) | MAOBSENP5SENP2SENP1CXCR2 | |
| SCHEMBL4632974 | 0.78 | ALDH1A1 (0.61) | CXCR2KMT2AMEN1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685122-B1 | BENZOFURANS AND BENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| US-7371774-B2 | Benzofurans and benzothiophenes | MERCK PATENT GMBH (DE) | 2008-05-13 | — | — | US | disclosed |
| US-20070066680-A1 | Benzofurans and benzothiophenes | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066680-A1 | Benzofurans and benzothiophenes | INSR, GPR119, IGF1R | MAOB 2409/4885CNR2 1525/4885CNR1 732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.