SCHEMBL46062

SCHEMBL46062

CON1CCC(N)(N(C)C(=O)Cc2cc(Br)c(F)cc2C)CC1

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.32
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
POLB P06746 1/20 0.31
HTT P42858 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL46350 0.91 TSHR (0.31) TSHR
SCHEMBL46128 0.87 L3MBTL1 (0.34) POLBL3MBTL1
SCHEMBL46050 0.86 OPRM1 (0.32) KDM4EALDH1A1TSHRMEN1KMT2A
SCHEMBL46051 0.86 ERBB2 (0.30) L3MBTL1
SCHEMBL15032119 0.85 RXFP1 (0.32) KDM4E
SCHEMBL12071754 0.83 SIGMAR1 (0.33) TSHRMEN1KMT2A
SCHEMBL46058 0.81 KDM4E (0.34) KDM4EALDH1A1MEN1KMT2APOLB
SCHEMBL46336 0.81 MAPT (0.35) ALDH1A1MEN1KMT2AL3MBTL1
SCHEMBL12071745 0.80 EZH2 (0.32) KDM4EALDH1A1MEN1KMT2APOLB
SCHEMBL12071073 0.80 KDM4E (0.32) KDM4EALDH1A1TSHRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011151249-A2 METHOD OF CONTROLLING NEONICOTINOID RESISTANT HEMIPTERA SYNGENTA PARTICIPATIONS AG (CH) 2011-12-08 WO disclosed
WO-2010066780-A1 SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-06-17 WO disclosed