Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2342911 | 1.00 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2TP53PGR | |
| SCHEMBL4607464 | 1.00 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2TP53PGR | |
| SCHEMBL11249889 | 0.86 | LMNA (0.49) | ALDH1A1LMNASMN1; SMN2TP53PGR | |
| SCHEMBL1061794 | 0.86 | LMNA (0.49) | ALDH1A1LMNASMN1; SMN2TP53PGR | |
| SCHEMBL2968427 | 0.86 | LMNA (0.49) | ALDH1A1LMNASMN1; SMN2TP53PGR | |
| SCHEMBL4826846 | 0.84 | MLYCD (0.55) | ALDH1A1LMNASMN1; SMN2TP53PGR | |
| SCHEMBL2588919 | 0.84 | MLYCD (0.55) | ALDH1A1LMNASMN1; SMN2TP53PGR | |
| SCHEMBL8040628 | 0.84 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2TP53PGR | |
| SCHEMBL8709763 | 0.84 | LMNA (0.47) | ALDH1A1LMNASMN1; SMN2TP53PGR | |
| SCHEMBL10576787 | 0.84 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2TP53PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783577-B1 | CHIMERIC RECEPTORS AND METHODS FOR IDENTIFYING COMPOUNDS ACTIVE AT METABOTROPIC GLUTAMATE RECEPTORS AND THE USE OF SUCH COMPOUNDS IN THE TREATMENT OF NEUROLOGICAL DISORDERS AND DISEASES | ASTRAZENECA AB (SE) | 2008-07-09 | — | — | EP | disclosed |
| EP-0882065-B1 | NOVEL HUMAN METABOTROPIC GLUTAMATE RECEPTOR | NPS PHARMA INC (US) | 2007-08-08 | — | — | EP | disclosed |
| EP-1687402-A4 | CHIMERIC METABOTROPIC GLUTAMATE RECEPTORS AND USES THEREOF | NPS PHARMA INC (US) | 2007-08-01 | — | — | EP | disclosed |
| US-7241863-B2 | Human metabotropic glutamate receptor | NPS PHARMACEUTICALS, INC. (US) | 2007-07-10 | — | — | US | disclosed |
| EP-1687402-A2 | CHIMERIC METABOTROPIC GLUTAMATE RECEPTORS AND USES THEREOF | NPS PHARMACEUTICALS, INC. (US) | 2006-08-09 | — | — | EP | disclosed |
| US-20050186658-A1 | Chimeric metabotropic glutamate receptors and uses thereof | NPS PHARMACEUTICALS, INC. | 2005-08-25 | — | — | US | disclosed |
| EP-1226164-A4 | HUMAN METABOTROPIC GLUTAMATE RECEPTOR | NPS PHARMA INC (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2005038006-A2 | CHIMERIC METABOTROPIC GLUTAMATE RECEPTORS AND USES THEREOF | NPS PHARMACEUTICALS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |
| US-20030157647-A1 | Novel human metabotropic glutamate receptor | ASTRAZENECA AB (SE) | 2003-08-21 | — | — | US | disclosed |
| US-20030113873-A1 | Chimeric receptors and methods for identifying compounds active at metabotropic glutamate receptors and the use of such compounds in the treatment of neurological disorders and diseases | NPS PHARMACEUTICALS | 2003-06-19 | — | — | US | disclosed |
| WO-2001030829-A1 | A NOVEL HUMAN METABOTROPIC GLUTAMATE RECEPTOR | NPS PHARMACEUTICALS, INC. (US) | 2001-05-03 | — | — | WO | disclosed |
| US-6084084-A | NUCLEOTIDE AND AMINO ACID SEQUENCES; FOR ANTICONVULSANTS, NEUROPROTECTANTS, ANALGESICS AND COGNITION ENHANCERS; FOR DIAGNOSIS AND THERAPY OF RELATED NERVOUS SYSTEM DISORDERS | NPS PHARMACEUTICALS, INC. (US) | 2000-07-04 | — | — | US | disclosed |
| US-6077675-A | DRUG SCREENING BY CONTACTING COMPOUND WITH RECOMBINANT CELL WHICH EXPRESSES A NUCLEIC ACID ENCODING THE RECEPTOR AND MONITORING FOR BINDING OR MODULATION OF RECEPTOR; ANTICONVULSANTS; ANALGESICS; COGNITION ENHANCERS | NPS PHARMACEUTICALS, INC. (US) | 2000-06-20 | — | — | US | disclosed |
| US-6051688-A | AMINO ACID SEQUENCE FOR POLYPEPTIDE OF AT LEAST 6 CONTIGUOUS AMINO ACIDS; FOR DIAGNOSIS AND TREATMENT OF NERVOUS SYSTEM DISORDERS; ANTICONVULSANTS; ANTIISCHEMIC/ANTIHYPOXIC AGENTS; ANTIEPILEPTIC AGENTS; ALZHEIMER'S/PARKINSON'S DISEASES | NPS PHARMACEUTICALS, INC. (US) | 2000-04-18 | — | — | US | disclosed |
| US-5981195-A | HYBRID G-PROTEIN BINDING RECEPTOR SITES; DETECTING THE SITE OF ACTION OF COMPOUND ON RECEPTOR; SCREENING FOR MODULATORS OF RECEPTOR; FOR TREATMENT OF NERVOUS SYSTEM DISORDERS; MUSCLE RELAXANTS; ANALGESICS | NPS PHARMACEUTICALS, INC. (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0882065-A2 | NOVEL HUMAN METABOTROPIC GLUTAMATE RECEPTOR | NPS PHARMACEUTICALS, INC. (US) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997048724-A2 | HUMAN METABOTROPIC GLUTAMATE RECEPTOR | NPS PHARMACEUTICALS, INC. (US) | 1997-12-24 | — | — | WO | disclosed |
| EP-0783577-A1 | CHIMERIC RECEPTORS AND METHODS FOR IDENTIFYING COMPOUNDS ACTIVE AT METABOTROPIC GLUTAMATE RECEPTORS AND THE USE OF SUCH COMPOUNDS IN THE TREATMENT OF NEUROLOGICAL DISORDERS AND DISEASES | NPS PHARMACEUTICALS, INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| WO-1997005252-A2 | CHIMERIC RECEPTORS AND METHODS FOR IDENTIFYING COMPOUNDS ACTIVE AT METABOTROPIC GLUTAMATE RECEPTORS AND THE USE OF SUCH COMPOUNDS IN THE TREATMENT OF NEUROLOGICAL DISORDERS AND DISEASES | NPS PHARMACEUTICALS, INC. (US) | 1997-02-13 | — | — | WO | disclosed |
| WO-1996005818-A1 | METHODS AND COMPOUNDS ACTIVE AT METABOTROPIC GLUTAMATE RECEPTORS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS AND DISEASES | NPS PHARMACEUTICALS, INC. (US) | 1996-02-29 | — | — | WO | disclosed |