Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 7/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608144 | 0.82 | SLC9A1 (0.50) | SIRT2SIRT1HTR2AHTR2CHTR2B | |
| SCHEMBL808740 | 0.82 | SLC9A1 (0.54) | HTR2AHTR2CHTR2BSLC9A1KDM1A | |
| SCHEMBL2397845 | 0.82 | SLC9A1 (0.54) | HTR2AHTR2CHTR2BSLC9A1KDM1A | |
| SCHEMBL4607572 | 0.80 | GRIA4 (0.47) | GRIA4SIRT2SIRT1HTR2AHTR2C | |
| SCHEMBL4608380 | 0.79 | SIRT2 (0.52) | GRIA4SIRT2SIRT1SLC9A1GRM4 | |
| SCHEMBL4607106 | 0.78 | SLC6A4 (0.43) | SIRT2SIRT1SLC9A1KDM1ANR3C2 | |
| SCHEMBL4608244 | 0.77 | SIRT2 (0.40) | SIRT2SIRT1SLC9A1NR3C2RAB9A | |
| SCHEMBL4606744 | 0.76 | KDM1A (0.43) | SLC9A1KDM1AMAOANR3C2MAOB | |
| SCHEMBL4371164 | 0.76 | SLC6A4 (0.43) | GRIA4SIRT2SIRT1 | |
| SCHEMBL4606990 | 0.76 | ALDH1A1 (0.49) | GRIA4SIRT2SIRT1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | claimed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | claimed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |